Mouse Rnf183 activation kit by CRISPRa

SKU GA210427

Rnf183 CRISPRa kit - CRISPR gene activation of mouse ring finger protein 183

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Rnf183
• Locus ID: 76072
• Components:

  GA210427G1, Rnf183 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA210427G2, Rnf183 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA210427G3, Rnf183 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_153504
• UniProt ID: Q8QZS5
• Synonyms: 5830442J12Rik
• Summary: Acts as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:29300766). Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1 (By similarity). May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling (By similarity).[UniProtKB/Swiss-Prot Function]