Mouse Rnf139 activation kit by CRISPRa

SKU GA210372

Rnf139 CRISPRa kit - CRISPR gene activation of mouse ring finger protein 139

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Rnf139
• Locus ID: 75841
• Components:

  GA210372G1, Rnf139 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA210372G2, Rnf139 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA210372G3, Rnf139 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_175226
• UniProt ID: Q7TMV1
• Synonyms: 4930555P18Rik
• Summary: E3-ubiquitin ligase; acts as a negative regulator of the cell proliferation through mechanisms involving G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the SREBP/SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination. May function as a signaling receptor.[UniProtKB/Swiss-Prot Function]