Mouse Kmt2b activation kit by CRISPRa

SKU GA210202

Kmt2b CRISPRa kit - CRISPR gene activation of mouse lysine (K)-specific methyltransferase 2B

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Kmt2b
• Locus ID: 75410
• Components:

  GA210202G1, Kmt2b gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA210202G2, Kmt2b gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA210202G3, Kmt2b gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001290573, NM_029274
• UniProt ID: O08550
• Synonyms: 2610014H22Rik; mKIAA0304; Mll2; Wbp7
• Summary: Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (By similarity). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development. Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation.[UniProtKB/Swiss-Prot Function]