Mouse Nmnat3 activation kit by CRISPRa

SKU GA209707

Nmnat3 CRISPRa kit - CRISPR gene activation of mouse nicotinamide nucleotide adenylyltransferase 3

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Nmnat3
• Locus ID: 74080
• Components:

  GA209707G1, Nmnat3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA209707G2, Nmnat3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA209707G3, Nmnat3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_144533, NM_001357445, NM_001357446, NM_001357449, NM_001357451, NM_001357452
• UniProt ID: Q99JR6
• Synonyms: 4933408N02Rik; PNAT3
• Summary: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury.[UniProtKB/Swiss-Prot Function]