Mouse Ppp2r2b activation kit by CRISPRa

SKU GA209367

Ppp2r2b CRISPRa kit - CRISPR gene activation of mouse protein phosphatase 2, regulatory subunit B, beta

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Ppp2r2b
• Locus ID: 72930
• Components:

  GA209367G1, Ppp2r2b gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA209367G2, Ppp2r2b gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA209367G3, Ppp2r2b gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_027531, NM_028392, NR_073583
• UniProt ID: Q6ZWR4
• Synonyms: 2900026H06Rik; 6330404L05Rik; E130009M08Rik; PP2A-PR55B; PR55-BETA; SCA12
• Summary: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity. Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance.[UniProtKB/Swiss-Prot Function]