Mouse Plekhf1 activation kit by CRISPRa

SKU GA209184

Plekhf1 CRISPRa kit - CRISPR gene activation of mouse pleckstrin homology domain containing, family F (with FYVE domain) member 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Plekhf1
• Locus ID: 72287
• Components:

  GA209184G1, Plekhf1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA209184G2, Plekhf1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA209184G3, Plekhf1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_024413
• UniProt ID: Q3TB82
• Synonyms: 1810013P09Rik; APPD; LAPF; PHAFIN1; ZFYVE15
• Summary: May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8 (By similarity).[UniProtKB/Swiss-Prot Function]