Mouse Aox3 activation kit by CRISPRa

SKU GA208913

Aox3 CRISPRa kit - CRISPR gene activation of mouse aldehyde oxidase 3

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Aox3
• Locus ID: 71724
• Components:

  GA208913G1, Aox3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA208913G2, Aox3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA208913G3, Aox3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_023617
• UniProt ID: G3X982
• Synonyms: 1200011D03Rik; AI326299; Aoh1; Aoh2
• Summary: Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and phthalazine, as well as aldehydes, such as benzaldehyde, retinal and pyridoxal. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor.[UniProtKB/Swiss-Prot Function]