Mouse Prxl2a activation kit by CRISPRa

SKU GA208559

Prxl2a CRISPRa kit - CRISPR gene activation of mouse peroxiredoxin like 2A

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Prxl2a
• Locus ID: 70564
• Components:

  GA208559G1, Prxl2a gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA208559G2, Prxl2a gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA208559G3, Prxl2a gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001316732, NM_001316733, NM_001316734, NM_001316735, NM_001316736, NM_001316737, NM_001316739, NM_001316740, NM_027464
• UniProt ID: Q9CYH2
• Synonyms: 5730469M10Rik; Adrx; AU040822; Pamm
• Summary: Involved in redox regulation of the cell (By similarity). Acts as an antioxidant (By similarity). Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation (By similarity). May affect bone resorption and help to maintain bone mass (By similarity). Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway (PubMed:26438880).[UniProtKB/Swiss-Prot Function]