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Mouse Scnm1 activation kit by CRISPRa

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SKU
GA208110
Scnm1 CRISPRa kit - CRISPR gene activation of mouse sodium channel modifier 1
  $1,657.00
4 Weeks*

Other products for "Scnm1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Scnm1
Locus ID 69269
Components

GA208110G1, Scnm1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA208110G2, Scnm1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA208110G3, Scnm1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001163573, NM_027013
UniProt ID Q8K136
Synonyms 3110001I17Rik; Scnm1-ps
Summary Mutations in the voltage-gated sodium channel gene Scn8a lead to neurological problems in mice. For one particular mutation, Scn8amedJ, mice live to adulthood but have tremors and muscle weakness, among other problems, in all strains except those derived from C57BL6 mice. In these strains, the product of the Scnm1 gene (229 aa) partially overcomes the effects of the Scn8amedJ mutation. However, in C57BL6-derived mice, a one nt change in the penultimate exon creates a premature stop codon, truncating the Scnm1 protein at 186 aa. This truncated protein lacks the ability to overcome the effects of the Scn8amedJ mutation, and these mice suffer paralysis and juvenile death. provided by RefSeq, Jul 2009
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Documents
Resources
Other Versions
SKU Description Size Price
KN515391 Scnm1 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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