Mouse Nat8 activation kit by CRISPRa

SKU GA207801

Nat8 CRISPRa kit - CRISPR gene activation of mouse N-acetyltransferase 8 (GCN5-related)

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Nat8
• Locus ID: 68396
• Components:

  GA207801G1, Nat8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA207801G2, Nat8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA207801G3, Nat8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_023455, NM_001362060
• UniProt ID: Q9JIY7
• Synonyms: 0610037O16Rik; CCNAT; Cml4
• Summary: Acetylates the free alpha-amino group of cysteine S-conjugates to form mercapturic acids. This is the final step in a major route for detoxification of a wide variety of reactive electrophiles which starts with their incorporation into glutathione S-conjugates. The glutathione S-conjugates are then further processed into cysteine S-conjugates and finally mercapturic acids which are water soluble and can be readily excreted in urine or bile. Alternatively, may have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6-acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1. May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons (By similarity).[UniProtKB/Swiss-Prot Function]