Mouse Map1lc3b activation kit by CRISPRa

SKU GA207330

Map1lc3b CRISPRa kit - CRISPR gene activation of mouse microtubule-associated protein 1 light chain 3 beta

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Map1lc3b
• Locus ID: 67443
• Components:

  GA207330G1, Map1lc3b gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA207330G2, Map1lc3b gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA207330G3, Map1lc3b gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_026160, NM_001364358
• UniProt ID: Q9CQV6
• Synonyms: 1010001C15Rik; Atg8; LC3b; Map1lc3
• Summary: Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.[UniProtKB/Swiss-Prot Function]