Mouse Riox2 activation kit by CRISPRa

SKU GA207083

Riox2 CRISPRa kit - CRISPR gene activation of mouse ribosomal oxygenase 2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Riox2
• Locus ID: 67014
• Components:

  GA207083G1, Riox2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA207083G2, Riox2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA207083G3, Riox2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_025910
• UniProt ID: Q8CD15
• Synonyms: 1810047J07Rik; 2410057H13Rik; 3830408E23Rik; AI449204
• Summary: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39' (By similarity). May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.[UniProtKB/Swiss-Prot Function]