Mouse Crbn activation kit by CRISPRa

SKU GA206297

Crbn CRISPRa kit - CRISPR gene activation of mouse cereblon

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Crbn
• Locus ID: 58799
• Components:

  GA206297G1, Crbn gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA206297G2, Crbn gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA206297G3, Crbn gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_021449, NM_175357
• UniProt ID: Q8C7D2
• Synonyms: 2610203G15Rik; 2900045O07Rik; AF229032; AW108261; piL
• Summary: This gene encodes a protein with a Lon protease domain, a "regulators of G protein-signaling" (RGS)-like domain and a leucine zipper. It has been proposed to regulate the assembly and surface expression of large-conductance calcium-activated potassium channels in brain and to bind thalidomide. In humans mutation in this gene causes autosomal recessive nonsyndromic cognitive disability. In mouse deficiency of this gene serves as a model to study the molecular mechanisms governing learning and memory as they relate to intellectual disability. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]