Mouse Rec8 activation kit by CRISPRa

SKU GA206074

Rec8 CRISPRa kit - CRISPR gene activation of mouse REC8 meiotic recombination protein

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Rec8
• Locus ID: 56739
• Components:

  GA206074G1, Rec8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA206074G2, Rec8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA206074G3, Rec8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_020002, NM_001360389, NM_001360390
• UniProt ID: Q8C5S7
• Synonyms: mrec; Rec8L1
• Summary: Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II.[UniProtKB/Swiss-Prot Function]