Mouse Kcnj1 activation kit by CRISPRa

SKU GA205935

Kcnj1 CRISPRa kit - CRISPR gene activation of mouse potassium inwardly-rectifying channel, subfamily J, member 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Kcnj1
• Locus ID: 56379
• Components:

  GA205935G1, Kcnj1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA205935G2, Kcnj1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA205935G3, Kcnj1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001168354, NM_019659
• UniProt ID: O88335
• Synonyms: Kir1.1; ROMK; Romk2
• Summary: In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium (By similarity).[UniProtKB/Swiss-Prot Function]