Mouse Nox4 activation kit by CRISPRa

SKU GA205313

Nox4 CRISPRa kit - CRISPR gene activation of mouse NADPH oxidase 4

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Nox4
• Locus ID: 50490
• Components:

  GA205313G1, Nox4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA205313G2, Nox4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA205313G3, Nox4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001285833, NM_001285835, NM_015760
• UniProt ID: Q9JHI8
• Synonyms: AI648021
• Summary: Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB.[UniProtKB/Swiss-Prot Function]