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Mouse Pcsk1n activation kit by CRISPRa

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SKU
GA205258
Pcsk1n CRISPRa kit - CRISPR gene activation of mouse proprotein convertase subtilisin/kexin type 1 inhibitor
  $1,657.00
4 Weeks*

Other products for "Pcsk1n"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Pcsk1n
Locus ID 30052
Components

GA205258G1, Pcsk1n gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA205258G2, Pcsk1n gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA205258G3, Pcsk1n gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_013892
UniProt ID Q9QXV0
Synonyms AI848336; bLEN; KEP; lLEN; Pan3; PEN; PEN19; PEN20; proSAAS; SAAS; SAASCT
Summary May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 87 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity. The function of the processed secreted peptides is not known.UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN512974 Pcsk1n - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

file-alt Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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