Mouse Spo11 activation kit by CRISPRa

SKU
GA205064
Spo11 CRISPRa kit - CRISPR gene activation of mouse SPO11 meiotic protein covalently bound to DSB
  $1,657.00
4 Weeks*
Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Spo11
Locus ID 26972
Components

GA205064G1, Spo11 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA205064G2, Spo11 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA205064G3, Spo11 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_001083959, NM_001083960, NM_001305434, NM_012046
UniProt ID Q9WTK8
Synonyms AI449549; Spo11a; Spo11b
Summary Isoform 1: Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with TOP6BL, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (PubMed:26917764). The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2 (PubMed:22346761).UniProtKB/Swiss-Prot Function
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Other Versions
SKU Description Size Price
KN516635 Spo11 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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