Mouse Zw10 activation kit by CRISPRa

SKU GA205059

Zw10 CRISPRa kit - CRISPR gene activation of mouse zw10 kinetochore protein

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Zw10
• Locus ID: 26951
• Components:

  GA205059G1, Zw10 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA205059G2, Zw10 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA205059G3, Zw10 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_012039
• UniProt ID: O54692
• Synonyms: 6330566F14Rik; MmZw10
• Summary: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex. Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER (By similarity).[UniProtKB/Swiss-Prot Function]