Mouse Racgap1 activation kit by CRISPRa

SKU GA205047

Racgap1 CRISPRa kit - CRISPR gene activation of mouse Rac GTPase-activating protein 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Racgap1
• Locus ID: 26934
• Components:

  GA205047G1, Racgap1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA205047G2, Racgap1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA205047G3, Racgap1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001253808, NM_001253809, NM_012025
• UniProt ID: Q9WVM1
• Synonyms: AI227039; AI327394; Band25; gtl11; GTPase; MgcRacGAP; mKIAA1478
• Summary: Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells.[UniProtKB/Swiss-Prot Function]