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Mouse Xbp1 activation kit by CRISPRa

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SKU
GA204649
Xbp1 CRISPRa kit - CRISPR gene activation of mouse X-box binding protein 1
  $1,657.00
4 Weeks*

Frequently Bought Together (1)

TA362914 XBP1 Antibody - middle region
100 ul
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Other products for "Xbp1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Xbp1
Locus ID 22433
Components

GA204649G1, Xbp1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA204649G2, Xbp1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA204649G3, Xbp1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001271730, NM_013842
UniProt ID O35426
Synonyms D11Ertd39e; TREB-5; TREB5; XBP-1
Summary Functions as a transcription factor during endoplasmic reticulum stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development and the development of secretory tissues such as exocrine pancreas and salivary gland (PubMed:10425189, PubMed:10652269, PubMed:16362047, PubMed:17612490). Involved in differentiation of B lymphocytes to plasma cells and production of immunoglobulins. Modulates the cellular response to ER stress in a PIK3R-dependent manner. Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes (By similarity). Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions (PubMed:23529610). Functions also as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes prevention (PubMed:15486293).UniProtKB/Swiss-Prot Function
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Other Versions
SKU Description Size Price
KN519483 Xbp1 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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