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Mouse Wnt5a activation kit by CRISPRa

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SKU
GA204640
Wnt5a CRISPRa kit - CRISPR gene activation of mouse wingless-type MMTV integration site family, member 5A
  $1,657.00
4 Weeks*

Other products for "Wnt5a"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Wnt5a
Locus ID 22418
Components

GA204640G1, Wnt5a gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA204640G2, Wnt5a gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA204640G3, Wnt5a gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_001256224, NM_009524
UniProt ID P22725
Synonyms 8030457G12Rik; Wnt-5a
Summary Ligand for members of the frizzled family of seven transmembrane receptors (PubMed:17117926). Can activate or inhibit canonical Wnt signaling, depending on receptor context (PubMed:16602827). In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression (PubMed:16602827). Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration (PubMed:17117926). Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells (By similarity). Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle (PubMed:10021340). Inhibits type II collagen expression in chondrocytes (By similarity).UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN319455 Wnt5a - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN319455BN Wnt5a - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN319455LP Wnt5a - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN319455RB Wnt5a - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN519455 Wnt5a - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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