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Mouse Trp63 activation kit by CRISPRa

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SKU
GA204450
Trp63 CRISPRa kit - CRISPR gene activation of mouse transformation related protein 63
  $1,657.00
4 Weeks*

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Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Trp63
Locus ID 22061
Components

GA204450G1, Trp63 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA204450G2, Trp63 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA204450G3, Trp63 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001127259, NM_001127260, NM_001127261, NM_001127262, NM_001127263, NM_001127264, NM_001127265, NM_011641
UniProt ID O88898
Synonyms AI462811; Ket; P51/P63; P63; P73l; Tp63; Trp53rp1
Summary This gene encodes tumor protein p63, a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include tumor proteins p53, p63, and p73, which have high sequence similarity to one another. This similarity allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways, including direct and indirect protein interactions. This results in mutual regulation of target gene promoters. Tumor protein p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Both alternative splicing and the use of alternative promoters result in multiple transcript variants encoding different protein isoforms.provided by RefSeq, Dec 2009
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Documents
Resources
Other Versions
SKU Description Size Price
KN518286 Trp63 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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