Mouse Top2a activation kit by CRISPRa

SKU GA204414

Top2a CRISPRa kit - CRISPR gene activation of mouse topoisomerase (DNA) II alpha

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Top2a
• Locus ID: 21973
• Components:

  GA204414G1, Top2a gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA204414G2, Top2a gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA204414G3, Top2a gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_011623
• UniProt ID: Q01320
• Synonyms: Top-2
• Summary: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (PubMed:24321095).[UniProtKB/Swiss-Prot Function]