Mouse Nr2e1 activation kit by CRISPRa

SKU GA204374

Nr2e1 CRISPRa kit - CRISPR gene activation of mouse nuclear receptor subfamily 2, group E, member 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Nr2e1
• Locus ID: 21907
• Components:

  GA204374G1, Nr2e1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA204374G2, Nr2e1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA204374G3, Nr2e1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_152229
• UniProt ID: Q64104
• Synonyms: fierce; frc; Mtl1; Mtll; tailless; TLL; Tlx; XTLL
• Summary: Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). Regulates cell cycle progression in neural stem cells of rhe developing brain. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity. May be involved in retinoic acid receptor (RAR) regulation in retinal cells.[UniProtKB/Swiss-Prot Function]