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Mouse Tlr4 activation kit by CRISPRa

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SKU
GA204371
Tlr4 CRISPRa kit - CRISPR gene activation of mouse toll-like receptor 4
  $1,657.00
4 Weeks*

Other products for "Tlr4"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Tlr4
Locus ID 21898
Components

GA204371G1, Tlr4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA204371G2, Tlr4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA204371G3, Tlr4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_021297
UniProt ID Q9QUK6
Synonyms Lps; Ly87; Ran/M1; Rasl2-8
Summary This gene belongs to the evolutionarily-conserved Toll-like receptor family, whose members are type-1 transmembrane proteins that are involved in innate immunity. Toll-like receptors are characterized by an extracellular leucine-rich repeat domain that functions in ligand recognition and an intracellular toll/interleukin-1 receptor-like domain that is crucial for signal transduction. The receptor encoded by this gene mediates the innate immune response to bacterial lipopolysaccharide, a major component of the outer membrane of Gram-negative bacteria, through synthesis of pro-inflammatory cytokines and chemokines. In addition, this protein can recognize other pathogens from Gram-negative and Gram-positive bacteria as well as viral components. Mice deficient in this gene display a number of immune response-related phenotypes including hyporesponsiveness to bacterial lipopolysaccharide and increased levels of respiratory syncytial virus compared to controls. provided by RefSeq, Sep 2015
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Documents
Resources
Other Versions
SKU Description Size Price
KN517627 Tlr4 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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