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Mouse Tgfbr2 activation kit by CRISPRa

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SKU
GA204324
Tgfbr2 CRISPRa kit - CRISPR gene activation of mouse transforming growth factor, beta receptor II
  $1,657.00
4 Weeks*

Other products for "Tgfbr2"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Tgfbr2
Locus ID 21813
Components

GA204324G1, Tgfbr2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA204324G2, Tgfbr2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA204324G3, Tgfbr2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_009371, NM_029575
UniProt ID Q62312
Synonyms 1110020H15Rik; AU042018; DNIIR; RIIDN; TbetaR-II; TbetaRII; TBR-II
Summary Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways (By similarity).UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN317488 Tgfbr2 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN317488BN Tgfbr2 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN317488LP Tgfbr2 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN317488RB Tgfbr2 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN517488 Tgfbr2 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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