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Mouse Tdg activation kit by CRISPRa

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SKU
GA204276
Tdg CRISPRa kit - CRISPR gene activation of mouse thymine DNA glycosylase
  $1,657.00
4 Weeks*

Other products for "Tdg"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Tdg
Locus ID 21665
Components

GA204276G1, Tdg gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA204276G2, Tdg gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA204276G3, Tdg gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_011561, NM_172552, NM_001358517
UniProt ID P56581
Synonyms E130317C12Rik; JZA-3; Jza1
Summary DNA glycosylase that plays a key role in active DNA demethylation: specifically recognizes and binds 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in the context of CpG sites and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine (PubMed:21817016). Cannot remove 5-hydroxymethylcytosine (5hmC). According to an alternative model, involved in DNA demethylation by mediating DNA glycolase activity toward 5-hydroxymethyluracil (5hmU) produced by deamination of 5hmC (PubMed:21722948). Also involved in DNA repair by acting as a thymine-DNA glycosylase that mediates correction of G/T mispairs to G/C pairs: in the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. Its role in the repair of canonical base damage is however minor compared to its role in DNA demethylation. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine.UniProtKB/Swiss-Prot Function
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Documents
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Other Versions
SKU Description Size Price
KN317363 Tdg - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN317363BN Tdg - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN317363LP Tdg - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN317363RB Tdg - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN517363 Tdg - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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