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Mouse Tcf7l2 activation kit by CRISPRa

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SKU
GA204242
Tcf7l2 CRISPRa kit - CRISPR gene activation of mouse transcription factor 7 like 2, T cell specific, HMG box
  $1,657.00
4 Weeks*

Other products for "Tcf7l2"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Tcf7l2
Locus ID 21416
Components

GA204242G1, Tcf7l2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA204242G2, Tcf7l2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA204242G3, Tcf7l2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_001142918, NM_001142919, NM_001142920, NM_001142921, NM_001142922, NM_001142923, NM_001142924, NM_001331135, NM_001331136, NM_001331137, NM_001331138, NM_001331139, NM_001331140, NM_001331141, NM_001331142, NM_001331143, NM_001331144, NM_001331145, NM_001331146, NM_001331147, NM_001331148, NM_001331149, NM_001331150, NM_009333, NR_138565
UniProt ID Q924A0
Synonyms Tcf-4; Tcf4; TCF4B; TCF4E
Summary Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif CCTTTGATC in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1 (By similarity). Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN517329 Tcf7l2 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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