Mouse Suclg2 activation kit by CRISPRa

SKU GA204160

Suclg2 CRISPRa kit - CRISPR gene activation of mouse succinate-Coenzyme A ligase, GDP-forming, beta subunit

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Suclg2
• Locus ID: 20917
• Components:

  GA204160G1, Suclg2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA204160G2, Suclg2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA204160G3, Suclg2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001326558, NM_011507
• UniProt ID: Q9Z2I8
• Synonyms: AF171077; AW556404; D6Wsu120e; G-SCS; GTPSCS; SCS-betaG
• Summary: GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.[UniProtKB/Swiss-Prot Function]