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Mouse Smarcb1 activation kit by CRISPRa

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SKU
GA203980
Smarcb1 CRISPRa kit - CRISPR gene activation of mouse SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
  $1,657.00
4 Weeks*

Other products for "Smarcb1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Smarcb1
Locus ID 20587
Components

GA203980G1, Smarcb1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA203980G2, Smarcb1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA203980G3, Smarcb1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_001161853, NM_011418
UniProt ID Q9Z0H3
Synonyms AU020204; Baf47; Ini1; Snf5; SNF5/INI1
Summary Core component of the BAF (SWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN316287 Smarcb1 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN316287BN Smarcb1 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN316287LP Smarcb1 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN316287RB Smarcb1 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN516287 Smarcb1 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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