Mouse Slc8a1 activation kit by CRISPRa

SKU GA203967

Slc8a1 CRISPRa kit - CRISPR gene activation of mouse solute carrier family 8 (sodium/calcium exchanger), member 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Slc8a1
• Locus ID: 20541
• Components:

  GA203967G1, Slc8a1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA203967G2, Slc8a1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA203967G3, Slc8a1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001112798, NM_001286684, NM_011406, NR_104580
• UniProt ID: P70414
• Synonyms: AI852629; AV344025; D930008O12Rik; Ncx1
• Summary: Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:8659820). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline (PubMed:10967099). Required for normal embryonic heart development and the onset of heart contractions (PubMed:10967099).[UniProtKB/Swiss-Prot Function]