Mouse Spi1 activation kit by CRISPRa

SKU GA203852

Spi1 CRISPRa kit - CRISPR gene activation of mouse spleen focus forming virus (SFFV) proviral integration oncogene

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Spi1
• Locus ID: 20375
• Components:

  GA203852G1, Spi1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA203852G2, Spi1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA203852G3, Spi1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_011355
• UniProt ID: P17433
• Synonyms: Dis-1; Dis1; PU.1; Sfpi-1; Sfpi1; Spi-1; Tcfpu1; Tfpu.1
• Summary: Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing.[UniProtKB/Swiss-Prot Function]