Mouse Polr2c activation kit by CRISPRa

SKU GA203703

Polr2c CRISPRa kit - CRISPR gene activation of mouse polymerase (RNA) II (DNA directed) polypeptide C

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Polr2c
• Locus ID: 20021
• Components:

  GA203703G1, Polr2c gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA203703G2, Polr2c gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA203703G3, Polr2c gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_009090
• UniProt ID: P97760
• Synonyms: 33kDa; mRBP31; RPB3; Rpo2-3
• Summary: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft (By similarity).[UniProtKB/Swiss-Prot Function]