Mouse Polr1c activation kit by CRISPRa

SKU GA203698

Polr1c CRISPRa kit - CRISPR gene activation of mouse polymerase (RNA) I polypeptide C

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Polr1c
• Locus ID: 20016
• Components:

  GA203698G1, Polr1c gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA203698G2, Polr1c gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA203698G3, Polr1c gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_009085
• UniProt ID: P52432
• Synonyms: 40kDa; AA409007; AA959927; AL024089; Polr1e; RPA40; Rpo1-1
• Summary: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).[UniProtKB/Swiss-Prot Function]