Mouse Ptpra activation kit by CRISPRa

SKU GA203484

Ptpra CRISPRa kit - CRISPR gene activation of mouse protein tyrosine phosphatase, receptor type, A

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Ptpra
• Locus ID: 19262
• Components:

  GA203484G1, Ptpra gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA203484G2, Ptpra gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA203484G3, Ptpra gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001163688, NM_008980, NM_001355161
• UniProt ID: P18052
• Synonyms: Ptpa; Ptpalpha; Rptpalpha; Rptra; Rptralpha
• Summary: Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation (PubMed:22801373). Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (PubMed:22801373).[UniProtKB/Swiss-Prot Function]