Mouse Pld2 activation kit by CRISPRa

SKU GA203283

Pld2 CRISPRa kit - CRISPR gene activation of mouse phospholipase D2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Pld2
• Locus ID: 18806
• Components:

  GA203283G1, Pld2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA203283G2, Pld2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA203283G3, Pld2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001302475, NM_001302476, NM_008876
• UniProt ID: P97813
• Synonyms: PLD1C
• Summary: This gene is a member of the phospholipase D (PLD) superfamily. The encoded protein catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. Phosphatidic acid is an essential intracellular lipid second messenger for many signaling pathways and has been implicated in a variety of physiological processes including cytoskeletal organization and cell proliferation. A similar gene in human may also function as a guanine nucleotide exchange factor (GEF) for the small GTPase Rac2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]