Mouse Pirb activation kit by CRISPRa

SKU GA203230

Pirb CRISPRa kit - CRISPR gene activation of mouse paired Ig-like receptor B

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Pirb
• Locus ID: 18733
• Components:

  GA203230G1, Pirb gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA203230G2, Pirb gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA203230G3, Pirb gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_011095, NM_001357394
• UniProt ID: P97484
• Synonyms: Gp91; Lilrb3; LIR-3; PIR-B
• Summary: May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM).[UniProtKB/Swiss-Prot Function]