Mouse Prf1 activation kit by CRISPRa

SKU GA203192

Prf1 CRISPRa kit - CRISPR gene activation of mouse perforin 1 (pore forming protein)

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Prf1
• Locus ID: 18646
• Components:

  GA203192G1, Prf1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA203192G2, Prf1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA203192G3, Prf1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_011073
• UniProt ID: P10820
• Synonyms: Pfn; Pfp; Prf-1
• Summary: Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.[UniProtKB/Swiss-Prot Function]