Mouse Pfn2 activation kit by CRISPRa

SKU GA203191

Pfn2 CRISPRa kit - CRISPR gene activation of mouse profilin 2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Pfn2
• Locus ID: 18645
• Components:

  GA203191G1, Pfn2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA203191G2, Pfn2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA203191G3, Pfn2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_019410
• UniProt ID: Q9JJV2
• Synonyms: Pfn
• Summary: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.[UniProtKB/Swiss-Prot Function]