Mouse Furin activation kit by CRISPRa

SKU GA203126

Furin CRISPRa kit - CRISPR gene activation of mouse furin (paired basic amino acid cleaving enzyme)

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Furin
• Locus ID: 18550
• Components:

  GA203126G1, Furin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA203126G2, Furin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA203126G3, Furin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001081454, NM_011046
• UniProt ID: P23188
• Synonyms: 9130404I01Rik; Fur; PACE; Pcsk3; SPC1
• Summary: This gene encodes a calcium-dependent serine endoprotease that proteolytically activates different proprotein substrates traversing the secretory pathway. The encoded protein undergoes proteolytic autoactivation during which an N-terminal propeptide is cleaved to generate the mature protein. Mice lacking the encoded protein die at an embryonic stage and display hemodynamic insufficiency, cardiac ventral closure defect, axial rotation defect and abnormal yolk sac vasculature. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]