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Mouse Tnfrsf11b activation kit by CRISPRa

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SKU
GA203048
Tnfrsf11b CRISPRa kit - CRISPR gene activation of mouse tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
  $1,657.00
4 Weeks*

Other products for "Tnfrsf11b"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Tnfrsf11b
Locus ID 18383
Components

GA203048G1, Tnfrsf11b gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA203048G2, Tnfrsf11b gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA203048G3, Tnfrsf11b gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_008764
UniProt ID O08712
Synonyms OCIF; Opg; TR1
Summary Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN517975 Tnfrsf11b - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

file-alt Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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