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Mouse Nrxn1 activation kit by CRISPRa

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SKU
GA202971
Nrxn1 CRISPRa kit - CRISPR gene activation of mouse neurexin I
  $1,657.00
4 Weeks*

Other products for "Nrxn1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Nrxn1
Locus ID 18189
Components

GA202971G1, Nrxn1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA202971G2, Nrxn1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA202971G3, Nrxn1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_020252, NM_177284
UniProt ID Q9CS84
Synonyms 1700062G21Rik; 9330127H16Rik; A230068P09Rik; mKIAA0578
Summary This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are synaptic transmembrane receptors that bind endogenous ligands that include neuroligins, dystroglycan, and neurexophilins. Neurexin complexes are required for efficient neurotransmission and are involved in synaptogenesis. In vertebrates, alternate promoter usage results in multiple isoform classes, of which the alpha and beta classes are the best characterized. In humans, allelic variants in this gene are associated with Pitt-Hopkins-like syndrome-2, while deletions have been associated with autism and schizophrenia. Mouse knockouts display decreased spontaneous and evoked vesicle release resulting in impaired synaptic transmission. In addition, knockout mice show altered social approach, reduced social investigation, reduced locomotor activity, and in males, increased aggression. Alternative splicing and promoter usage result in multiple transcript variants. provided by RefSeq, Nov 2016
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Documents
Resources
Other Versions
SKU Description Size Price
KN511249 Nrxn1 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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