Mouse Npr3 activation kit by CRISPRa

SKU GA202953

Npr3 CRISPRa kit - CRISPR gene activation of mouse natriuretic peptide receptor 3

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Npr3
• Locus ID: 18162
• Components:

  GA202953G1, Npr3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA202953G2, Npr3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA202953G3, Npr3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001039181, NM_001286395, NM_008728
• UniProt ID: P70180
• Synonyms: ANP-C; ANPR-C; EF-2; lgj; NPR-C; stri
• Summary: Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP (PubMed:10377427, PubMed:17951249). May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects (PubMed:10377427, PubMed:17951249). May regulate diuresis, blood pressure and skeletal development (PubMed:10377427). Does not have guanylate cyclase activity (PubMed:10377427).[UniProtKB/Swiss-Prot Function]