Mouse Npas1 activation kit by CRISPRa

SKU GA202943

Npas1 CRISPRa kit - CRISPR gene activation of mouse neuronal PAS domain protein 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Npas1
• Locus ID: 18142
• Components:

  GA202943G1, Npas1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA202943G2, Npas1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA202943G3, Npas1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_008718
• UniProt ID: P97459
• Synonyms: bHLHe11; MOP5
• Summary: May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level. Forms a heterodimer that binds core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) leading to transcriptional repression on its target gene TH (PubMed:27782878).[UniProtKB/Swiss-Prot Function]