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Mouse Notch2 activation kit by CRISPRa

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SKU
GA202937
Notch2 CRISPRa kit - CRISPR gene activation of mouse notch 2
  $1,657.00
4 Weeks*

Other products for "Notch2"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Notch2
Locus ID 18129
Components

GA202937G1, Notch2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA202937G2, Notch2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA202937G3, Notch2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_010928
UniProt ID O35516
Synonyms AI853703; N2
Summary Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination (PubMed:10393120). Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:10393120, PubMed:18710934). Affects the implementation of differentiation, proliferation and apoptotic programs (PubMed:10393120, PubMed:18710934). May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation (By similarity). In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:18710934). Positively regulates self-renewal of liver cancer cells (By similarity).UniProtKB/Swiss-Prot Function
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Documents
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Other Versions
SKU Description Size Price
KN311125 Notch2 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN311125BN Notch2 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN311125LP Notch2 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN311125RB Notch2 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN511125 Notch2 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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