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Mouse Nck1 activation kit by CRISPRa

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SKU
GA202840
Nck1 CRISPRa kit - CRISPR gene activation of mouse non-catalytic region of tyrosine kinase adaptor protein 1
  $1,657.00
4 Weeks*

Other products for "Nck1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Nck1
Locus ID 17973
Components

GA202840G1, Nck1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA202840G2, Nck1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA202840G3, Nck1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001324530, NM_010878
UniProt ID Q99M51
Synonyms 6330586M15Rik; D230010O13Rik; Nck; Nck-1
Summary Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA (By similarity).UniProtKB/Swiss-Prot Function
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Documents
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Other Versions
SKU Description Size Price
KN510779 Nck1 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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