Mouse Ppp1r15a activation kit by CRISPRa

SKU GA202781

Ppp1r15a CRISPRa kit - CRISPR gene activation of mouse protein phosphatase 1, regulatory subunit 15A

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Ppp1r15a
• Locus ID: 17872
• Components:

  GA202781G1, Ppp1r15a gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA202781G2, Ppp1r15a gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA202781G3, Ppp1r15a gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_008654
• UniProt ID: P17564
• Synonyms: 9630030H21; Gadd34; Myd116
• Summary: Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'. In case of infection with vesicular stomatitis virus (VSV), impairs viral replication.[UniProtKB/Swiss-Prot Function]