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Mouse Myc activation kit by CRISPRa

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SKU
GA202779
Myc CRISPRa kit - CRISPR gene activation of mouse myelocytomatosis oncogene
  $1,657.00
4 Weeks*

Other products for "Myc"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Myc
Locus ID 17869
Components

GA202779G1, Myc gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA202779G2, Myc gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA202779G3, Myc gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001177352, NM_001177353, NM_001177354, NM_010849
UniProt ID P01108
Synonyms AU016757; bHLHe39; Myc2; Niard; Nird
Summary The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma, in human. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini, in human and mouse. Under conditions of stress, such as high cell densities and methionine deprivation, there is a specific and dramatic increase in the synthesis of the non-AUG initiated protein, suggesting its importance in times of adversity. Alternative splicing results in multiple transcript variants. provided by RefSeq, Apr 2010
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Documents
Resources
Other Versions
SKU Description Size Price
KN510576 Myc - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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