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Mouse Msh6 activation kit by CRISPRa

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SKU
GA202722
Msh6 CRISPRa kit - CRISPR gene activation of mouse mutS homolog 6
  $1,657.00
4 Weeks*

Other products for "Msh6"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Msh6
Locus ID 17688
Components

GA202722G1, Msh6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA202722G2, Msh6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA202722G3, Msh6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_010830
UniProt ID P54276
Synonyms AU044881; AW550279; GTBP; Gtmbp
Summary Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction (By similarity).UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN310424 Msh6 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN310424BN Msh6 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN310424LP Msh6 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN310424RB Msh6 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN510424 Msh6 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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